High Grade Penile Intraepithelial Neoplasia

**Semantic type:** Neoplastic Process

**Definition:** Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy either the lower two thirds of the epithelial thickness (grade II) or the entire thickness of the epithelium (grade III, Bowen atypia, or squamous cell carcinoma in situ).

**Synonyms:** - High Grade PeIN