NLRP3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NLRP3 wild-type allele is located in the vicinity of 1q44 and is approximately 33 kb in length. This allele, which encodes NACHT, LRR and PYD domains-containing protein 3, is involved in the regulation of both apoptosis and inflammation. Mutation of the gene is associated with familial cold autoinflammatory syndrome, Muckle-Wells syndrome, and chronic infantile neurological cutaneous and articular syndrome.

**Synonyms:** - AGTAVPR - AII - AII/AVP - AVP - C1orf7 - CIAS1 - CLR1.1 - Cold Autoinflammatory Syndrome 1 Gene - Cryopyrin Gene - FCAS - FCU - FLJ95925 - MWS - NALP3 - NLR Family, Pyrin Domain Containing 3 wt Allele - Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat and Pyrin Domain Containing 3 Gene - PYPAF1