Prochlorperazine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI04)

**Synonyms:** - 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine - Compro - PROCHLORPERAZINE - RP 6140 - SKF-4657 - prochlorperazine