Prochlorperazine Maleate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension.

**Synonyms:** - Compazine - Compazine - Compazine - PROCHLORPERAZINE MALEATE - Prochlorperazine Dimaleate