Bufogenin

**Semantic type:** Pharmacologic Substance

**Definition:** A bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans; it is also one of the glycosides in the traditional Chinese medicine ChanSu, with potential cardiotonic activity. Although the mechanism of action of bufogenin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and has been shown to reduce blood pressure in a rat model of preeclampsia.

**Synonyms:** - 14,15-Beta-Epoxy-3-Beta-Hydroxy-5-Beta-Bufa-20,22-Dienolide - 14,15beta-Epoxy-3beta-Hydroxy-5beta-Bufa-20,22-Dienolide - 3-Beta-Hydroxy-14,15-Beta-Epoxy-5-Beta-Bufa-20,22-Dienolide - 3beta-Hydroxy-14,15beta-Epoxy-5beta-Bufa-20,22-Dienolide - 5-Beta-Bufa-20,22-Dienolide, 14,15-Beta-Epoxy-3-Beta-Hydroxy- - 5beta-Bufa-20,22-Dienolide, 14,15beta-Epoxy-3beta-Hydroxy- (8CI) - BUFOGENIN - Bufa-20,22-Dienolide, 14,15-Epoxy-3-Hydroxy-, (3beta,5beta,15beta)- (9CI) - Resibufogenin - Respigon