Yttrium Y 90 DOTA Anti-CEA Monoclonal Antibody M5A

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A radioimmunoconjugate consisting of a monoclonal antibody directed against the human carcinoembryonic antigen (CEA) conjugated with the radioisotope yttrium 90 (Y-90) via the chelator tetra-azacyclododecanetetra-acetic acid (DOTA) with potential antineoplastic activity. The antibody moiety of yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A binds to cells expressing the CEA antigen. Upon cellular internalization, this agent selectively delivers a cytotoxic dose of beta radiation. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers.

**Synonyms:** - Y90-DOTA-M5A - YTTRIUM Y-90 DOTA ANTI-CEA MONOCLONAL ANTIBODY M5A - yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A