50% Oxygen/50% Nitrous Oxide Premix

**Semantic type:** Inorganic Chemical|Pharmacologic Substance

**Definition:** An equimolar gas mixture of oxygen (O2) and nitrous oxide (N2O) with potential analgesic activity. Upon inhalation, 50% oxygen/50% nitrous oxide premix produces rapidly reversible analgesia. The exact mechanism through which nitrous oxide exerts its analgesic effect has yet to be fully elucidated, but it appears to be associated with the neuronal release of endogenous opioid peptides.

**Synonyms:** - Entonox - Kalinox 170 Bar - Premixed Nitrous Oxide and Oxygen 50/50