Aprosulate Sodium

**Semantic type:** Pharmacologic Substance

**Definition:** The sodium salt form of aprosulate, a synthetic sulfated bis(lactobionic acid amide) derivative and heparin analogue with anticoagulant activity. Aprosulate is made up of two fully sulfated lactobionic acid moieties with a diamine spacer via two amide bonds. This agent inhibits thrombin by antagonizing heparin cofactor II (HCII) and thus blocking thrombin-induced platelet aggregation. It prolongs clotting time.

**Synonyms:** - APROSULATE SODIUM - D-Gluconamide, N,N'-1,3-propanediylbis(4-O-(2,3,4,6-tetra-O-sulfo-beta-D-galactopyranosyl))-, 2,2',3,3',5,5',6,6'-octakis(hydrogen sulfate), Hexadecasodium Salt - N,N'-Trimethylenebis(actobionamide) Hexadecakis(Sodium Sulfate) (Ester)