NQO1*2 Allele

**Semantic type:** Gene or Genome

**Definition:** Human NQO1*2 allele is located in the vicinity of 16q22.1 and is approximately 17 kb in length. The NQO1 *2 allele has a C609T substitution in the cDNA, which encodes NAD(P)H dehydrogenase [quinone] 1*2 protein that results in the amino acid change P187S. The NQO1*2 protein has both diminished catalytic activity and altered degradation by the ubiquitin-proteasomal system. Expression of this allele is associated with increased risk of benzene hematotoxicity, asthma and leukemias and decreased breast cancer survival.

**Synonyms:** - NAD(P)H Dehydrogenase, Quinone 1*2 Allele - NQO1 C609T - NQO1 c. 609 C-T Allele - NQO1 p. P187S - NQO1 p. Pro187Ser - NQO1*2