EGF A61G Allele

**Semantic type:** Gene or Genome

**Definition:** Human EGF A61G allele is located in the vicinity of 4q25 and is approximately 99 kb in length. The A61G allele is a polymorphism in the promoter region of the EGF gene where an adenosine residue is replaced by a guanosine at position 61 in the genomic DNA, which encodes pro-epidermal growth factor precursor protein. This allele may be associated with aberrant expression of the protein and decreased incidence of cirrhosis, hepatocellular carcinoma, malignant melanoma and gastric cancer.

**Synonyms:** - EGF A61G - EGF g. 61 A-G Allele - EGF61*G - Epidermal Growth Factor (Beta-Urogastrone) 61*G Allele - Epidermal Growth Factor (Beta-Urogastrone) A61G Allele