mTOR Kinase Inhibitor CERC-006

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor, with potential antineoplastic activity. Upon oral administration, mTOR kinase inhibitor CERC-006 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway.

**Synonyms:** - AEVI 006 - AEVI-006 - AEVI006 - ASP 7486 - ASP-7486 - ASP7486 - CERC 006 - CERC-006 - CERC006 - Mammalian Target of Rapamycin Kinase Inhibitor OSI-027 - OSI-027 - OSI-027 - mTOR Kinase Inhibitor OSI-027