Astuprotimut-R

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A cancer vaccine consisting of a recombinant form of human melanoma antigen A3 (MAGE-A3) combined with a proprietary adjuvant with potential immunostimulatory and antineoplastic activities. Upon administration, astuprotimut-R may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the MAGE-A3 antigen, resulting in tumor cell death. MAGE-A3, a tumor-associated antigen (TAA) originally discovered in melanoma cells, is expressed by various tumor types. The proprietary immunostimulating adjuvant in this agent is composed of a specific combination of immunostimulating compounds selected to increase the anti-tumor immune response to MAGE-A3.

**Synonyms:** - ASTUPROTIMUT-R - GSK1203486A - GSK1572932A - Immunotherapeutic GSK1572932A - MAGE-A3 - Recombinant MAGE-A3 ASCI GSK1203486A