Iofolastat I123

**Semantic type:** Pharmacologic Substance

**Definition:** An iodine 123-radiolabeled small molecule that exhibits high affinity for prostate-specific membrane antigen (PSMA) with potential use in molecular imaging. Iofolastat I123, a radiolabeled glutamate-urea-lysine analogue, selectively binds PSMA, which allows imaging of PSMA-expressing prostate cancer cells with gamma scintigraph. PSMA is a transmembrane glycoprotein highly expressed by malignant prostate epithelial cells and vascular endothelial cells of various solid tumors.

**Synonyms:** - 123-I-MIP-1072 - IOFOLASTAT I-123 - Iodine I 123 MIP-1072 - L-Glutamic Acid, N-((((1S)-1-carboxy-5-(((4-(iodo-123i)phenyl)methyl)amino)pentyl)amino)carbonyl)- - N-(((1S)-1-carboxy-5-(((4-((Sup 123)i)iodophenyl)methyl)amino)pentyl)carbamoyl)-L-glutamic Acid