CD4+ CD25+ Regulatory T Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** Regulatory T cells that express CD4 and CD25 (interleukin 2 receptor) antigens, with immunomodulating activity. CD4+CD25+ T regulatory cells (Tregs), a subset of CD4+ T cells expressing high levels of CD25 and the transcription factor Foxp3, are essential in maintaining immunologic homeostasis, preventing autoimmunity by suppressing self-reactive T cells; CD4+CD25+ Tregs may induce tolerance to allogeneic organ transplants such as hematopoetic stem cell transplants (HSCTs).

**Synonyms:** - CD4+ CD25+ FOXP3+ Regulatory T Cells - T reg - T-regulatory cell - regulatory T cell - suppressor T cell