Breast Ductal Carcinoma In Situ, High Grade

**Semantic type:** Neoplastic Process

**Definition:** Breast ductal carcinoma in situ characterized by the presence of neoplastic cells with severe dysplasia and the formation of micropapillary, cribriform, or solid patterns. The nuclei show marked pleomorphism and have prominent nucleoli. Mitotic activity is usually present. There is comedo-type of necrosis present in the ducts. The necrotic debris is surrounded by pleomorphic malignant cells.

**Synonyms:** - DCIS Grade 3 - DIN 3 - DIN 3 - Ductal Intraepithelial Neoplasia, Grade 3 - High Grade Ductal Breast Carcinoma In Situ - High Grade Ductal Breast Carcinoma In Situ - High-Grade DCIS of Breast - High-Grade DCIS of the Breast - High-Grade Ductal Carcinoma In Situ of Breast - grade III ductal carcinoma in situ