Celgosivir

**Semantic type:** Pharmacologic Substance

**Definition:** A 6-0-butanoyl ester derivative of castanospermine, a compound derived from the Australian chestnut with activity against hepatitis C virus. Celgosivir rapidly converts to castanospermine in the body, where it is a potent inhibitor of alpha-glucosidase I, a host enzyme required for viral assembly, release, and infectivity.

**Synonyms:** - (1S,6S,7S,8R,8aR)-Octahydro-1,7,8-trihydroxy-6-indolizinyl Butyrate - 6-O-Butanoylcastanospermine - CELGOSIVIR - MBI-3253 - MDL-28574 - MX-3253