Namodenoson

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Namodenoson selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation.

**Synonyms:** - 2-Chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide - 2-Cl-IB-MECA - A3AdR Agonist CF102 - Adenosine Receptor A3 Agonist CF102 - C-Ibza-MU - CF102 - NAMODENOSON - beta-D-Ribofuranuronamide, 1-(2-Chloro-6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-1-deoxy-N-methyl-