Irosustat

**Semantic type:** Pharmacologic Substance

**Definition:** Steroid sulfatase inhibitor BN 83495 selectively binds to and inhibits steroid sulfatase (STS), which may inhibit the production of locally active estrogens and so inhibit estrogen-dependent cell growth in tumor cells, such as those of the breast, ovary, and endometrium. STS is a cytoplasmic enzyme responsible for the conversion of circulating inactive estrone sulfate and estradiol sulfate to biologically active unconjugated estrone and estradiol, respectively.

**Synonyms:** - 667 Coumate - BN83495 - IROSUSTAT - STX 64 - Steroid Sulfatase Inhibitor BN 83495