Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** Autologous human peripheral blood lymphocytes (PBLs), transduced with a retroviral vector encoding both the alpha and beta chains of a T cell receptor (TCR) specific for the carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, anti-CEA TCR retroviral vector-transduced autologous lymphocytes bind to tumor cells expressing CEA, which may result in cytokine expression, activation and proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. The tumor-associated antigen (TAA) CEA is overexpressed by a variety of cancer cell types, including those of the gastrointestinal tract, lung, and breast.

**Synonyms:** - Anti-CEA TCR Retroviral Vector-Transduced Autologous PBLs - Anti-CEA TCR-Gene Engineered Autologous Lymphocytes