TMPRSS2/ERG Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a genetic translocation event which fuses the 5' end of the androgen-regulated TMPRSS2 gene with the entire coding region of the ERG gene. The androgen-dependent expression of this fusion gene results in overexpression of ERG activity.

**Synonyms:** - ERG/TMPRSS2 Fusion Gene - T2:ERG - TMPRSS2-ERG Fusion Gene - TMPRSS2::ERG Fusion Gene - Transmembrane Protease, Serine 2/V-Ets Erythroblastosis Virus E26 Oncogene Homolog (Avian) Fusion Gene