TARDBP wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TARDBP wild-type allele is located in the vicinity of 1p36.22 and is approximately 13 kb in length. This allele, which encodes TAR DNA-binding protein 43, plays a role in the mediation of both mRNA splicing and DNA transcription. Mutation of the gene is associated with amyotrophic lateral sclerosis type 10.

**Synonyms:** - ALS10 - TAR DNA Binding Protein wt Allele - TAR DNA-Binding Protein, 43-kD Gene - TDP-43 - TDP43