Ioflubenzamide I-131

**Semantic type:** Pharmacologic Substance

**Definition:** An iodine 131-radiolabeled small-molecule benzamide compound with potential antineoplastic activity. The benzamide moiety of 131-I-MIP-1145 binds to melanin, selectively delivering a cyotoxic dose of gamma and beta radiation to melanin-expressing tumor cells. Melanin pigments, polymer derivatives of the amino acid tyrosine, are over-expressed in approximately 40% of melanomas.

**Synonyms:** - IOFLUBENZAMIDE I-131 - Ioflubenzamide (131I) - MIP-1145 - N-(2-(diethylamino)ethyl)-4-((4-fluorobenzoyl)amino)-5-((sup 131)I)iodo-2-methoxybenzamide