RAG1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RAG1 wild-type allele is located in the vicinity of 11p13 and is approximately 12 kb in length. This allele, which encodes V(D)J recombination-activating protein 1, plays a role in the mediation of immunoglobulin recombination. Mutation of the gene is associated with several hereditary immunodeficiencies. Genetic variation may be associated with the relapse of acute lymphoblastic leukemia.

**Synonyms:** - MGC43321 - RAG-1 - RING Finger Protein 74 Gene - RNF74 - Recombination Activating 1 wt Allele - Recombination Activating Gene 1 Gene - Recombination Activating Protein 1 Gene - Recombination-Activating Gene 1 Gene - V(D)J Recombination-Activating Protein 1 Gene