Safingol Hydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The hydrochloride salt of a saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.

**Synonyms:** - (2S,3S)-2-Amino-1,3-Octadecanediol Hydrochloride - 1,3-Octadecanediol, 2-amino-, Hydrochloride, (S-(R*,R*))- - SAFINGOL HYDROCHLORIDE - SPC-100271 - Safingol HCl