Granisetron Transdermal Patch

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A transdermal system containing granisetron, a selective serotonin (5-HT) receptor antagonist, with antiemetic activity. Upon application of the transdermal patch to the skin and subsequent release into the bloodstream, granisetron selectively binds to and blocks the 5-HT subtype 3 (5-HT3) receptors located in the vagus nerve terminal and in the vomiting center in the central nervous system (CNS). By preventing stimulation of 5-HT3 receptors, this agent is able to suppress chemotherapy-induced nausea and vomiting.

**Synonyms:** - 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide - Granisetron Transdermal System - Sancuso