Lapine T-Lymphocyte Immune Globulin

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A preparation of purified, pasteurized, gamma globulin obtained by the immunization of rabbits with human thymocytes, with T-cell depleting and immunosuppressive activities. Upon administration, rabbit anti-thymocyte globulin (rATG) specifically recognizes, modulates and destroys T-lymphocytes. Although the exact mechanism of action by which rATG causes immunosuppression is not completely understood, it is likely caused by a combination of T-lymphocyte depletion and reduction in T-cell activation and their cytotoxic activities. Administering ATG with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host disease (GvHD).

**Synonyms:** - Anti-Thymocyte Globulin Rabbit - Anti-thymocyte Globulin Rabbit - Antithymocyte Globulin Rabbit - Antithymocyte globulin rabbit ATG - Grafalon - Imtix - LAPINE T-LYMPHOCYTE IMMUNE GLOBULIN - Rabbit ATG - Rabbit Anti-Human Thymocyte Globulin (RATG) - Rabbit Anti-Thymocyte Globulin - Rabbit Antithymocyte Globulin - Thymoglobulin