Eptacog Alfa

**Semantic type:** Pharmacologic Substance

**Definition:** A recombinant form of the vitamin K-dependent glycoprotein and coagulation factor VIIa (FVIIa), that can be used for the treatment of bleeding episodes and perioperative management in patients with hemophilia, congenital Factor VII (FVII) deficiency, and Glanzmann's thrombasthenia. Upon intravenous administration, eptacog alfa temporarily replaces missing endogenous FVIIa. When complexed with tissue factor (TF), FVIIa activates coagulation Factor X (FX) to Factor Xa (FXa), as well as coagulation Factor IX to Factor IXa. Factor Xa, in complex with other factors, then converts prothrombin to thrombin. This converts fibrinogen to fibrin and leads to the formation of a hemostatic plug, thereby inducing local hemostasis and prevents bleeding.

**Synonyms:** - COAGULATION FACTOR VIIA RECOMBINANT HUMAN - Coagulation Factor VIIa Recombinant - Coagulation Factor VIIa Recombinant Human - Coagulation factor VIIa Recombinant Human - Factor VIIa recombinant - NovoSeven RT - Novoseven - Recombinant Coagulation Factor VIIa - Recombinant FVIIa - Recombinant Factor VIIa - rFVIIa