Dornase Alfa

**Semantic type:** Pharmacologic Substance

**Definition:** A recombinant human deoxyribonuclease I (rhDNAse) with selective DNA cleaving activity. Upon intrapleural administration, dornase alfa catalyzes the degradation of extracellular DNA in airway secretions, which can reduce their viscosity. Thus, dornase alfa may both promote the clearing of airway mucus and improve pulmonary function.

**Synonyms:** - DORNASE ALFA - Pulmozyme - Recombinant Human Deoxyribonuclease I