Transient Abnormal Myelopoiesis Associated with Down Syndrome

**Semantic type:** Neoplastic Process

**Definition:** A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes spontaneous remission.

**Synonyms:** - TAM - TAM - Transient Abnormal Myelopoiesis - Transient Abnormal Myelopoiesis (TAM) - Transient Myeloproliferative Disorder - Transient Myeloproliferative Disorder - Transient abnormal myelopoiesis