Cold Contaminant-free Iobenguane I-131

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** An I 131 radioiodinated synthetic analogue of the neurotransmitter norepinephrine, manufactured with a proprietary process, with radioisotopic and potential antineoplastic activities. Cold contaminant-free iobenguane I 131 (MIBG) localizes to adrenergic tissue and may be used to image or eradicate tumor cells that accumulate and metabolize norepinephrine. This agent is manufactured using a technology that avoids the production of unwanted "cold contaminants" (i.e., carrier molecules), which may cause undesirable side effects and compete with MIBG for binding on target receptor sites.

**Synonyms:** - Azedra - Cold Contaminant-free I 131-MIBG - Cold Contaminant-free Iobenguane I 131 - Ultratrace Iodine I 131 Metaiodobenzylguanidine - Ultratrace MIBG