Indium In 111-DOTA-di-HSG Peptide IMP-288

**Semantic type:** Pharmacologic Substance

**Definition:** A radiolabeled divalent histamine-succinyl-glycine (HSG) hapten-peptide linked with the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide indium (In) 111. After pretargeting with a bispecific monoclonal antibody (BiMoAB) directed against both a tumor associated antigen (TAA) and the HSG hapten-peptide, the HSG portion of administered indium-In-labeled di-HSG-DOTA peptide IMP-288 binds the anti-HSG portion of the BiMoAB; In-111 radioisotopic activity localized to tumor cells bearing the TAA can then be visualized scintigraphically.

**Synonyms:** - In-111-Labeled Di-Histamine-Succinyl-Glycine-DOTA Peptide IMP-288 - In-111-Labeled IMP-288