Sizofiran

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A soluble beta-D-glucan produced by the Basidiomycetes fungus, Schizophyllum commune Fries, with potential immunomodulating and antitumor activities. Although sizofiran's exact mechanism of action has yet to be fully elucidated, this agent appears to stimulate the immune system by increasing cytokine production, activating macrophages and enhancing the activity of polymorphonuclear leukocytes (PML) and natural killer (NK) cells.

**Synonyms:** - MC-Glucan - Poly(3-(O-beta-D-glucopyranosyl-(1-3)-O-(beta-D-glucopyranosyl-(1-6))-O-beta-D-glucopyranosyl-(1-3)-O-beta-D-glucopyranosyl)-1) - SIZOFIRAN - Schizophyllan - Schizophyllan - Schizophyllane - Sixofilan - Sonifilan