Immunocytokine NHS-IL2-LT

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A fusion protein consisting of a mouse-human chimeric antibody directed against DNA released by necrotic tumor cells fused to two molecules of a genetically modified human interleukin-2 (IL-2) with potential antineoplastic activity. Upon administration, the antibody moiety of immunocytokine NHS-IL2-LT binds to DNA released by necrotic tumor cells located primarily at the core of necrotic solid tumors, delivering the IL-2 moiety. In turn, the IL-2 moiety of this agent activates the immune system to mount a cytotoxic T lymphocyte response against nearby tumor cells.

**Synonyms:** - Ch.14.18-IL2 - EMD 521873 - Interleukin-2 Fusion Protein MSB0010445 - Interleukin-2 Fusion Protein MSB0010445 - MSB0010445 - NHS-IL2 - SELECTIKINE - Selectikine