Rimiducid

**Semantic type:** Pharmacologic Substance

**Definition:** A lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. This agent is used to homodimerize the Fv-containing drug-binding domains of genetically engineered receptors such as the iCD40 receptor of the autologous dendritic cell vaccine BP-GMAX-CD1, resulting in receptor activation.

**Synonyms:** - 2-Piperidinecarboxylic acid, 1-(1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl)-, 1,2-Ethanediylbis(imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene(3-(3,4-dimethoxyphenyl)propylidene)) Ester, (2S-(1(R*),2R*(S*(S*(1(R*),2R*)))))- - AP-1903 - AP1903 - RIMIDUCID