Nedocromil Calcium

**Semantic type:** Pharmacologic Substance

**Definition:** The calcium salt form of nedocromil, a pyranoquinolone derivative with anti-inflammatory properties. Nedocromil inhibits the activation and release of inflammatory mediators (leukotrienes, histamine and prostaglandins) from a variety of cells involved in hypersensitivity reactions, including mast cells, eosinophils, neutrophils, macrophages, monocytes and platelets. As a result, nedocromil sodium inhibits both immediate and late bronchoconstriction, decreases bronchial hyperresponsiveness and inhibits recruitment of other inflammatory cells into the airway epithelium.

**Synonyms:** - 4H-Pyrano(3,2-G)Quinoline-2,8-Dicarboxylic Acid, 9-Ethyl-6,9-Dihydro-4,6-Dioxo-10-Propyl-, Calcium Salt (1:1) - Calcium 9-Ethyl-6,9-Dihydro-4,6-Dioxo-10-Propyl-4H-Pyrano(3,2-G)Quinoline-2,8-Dicarboxylate (1:1) - FPL 59002KC - NEDOCROMIL CALCIUM