Sodium Salicylate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The sodium salt of salicylic acid. As a nonsteroidal anti-inflammatory drug (NSAID), sodium salicylate irreversibly acetylates cyclooxygenases I and II, thereby inhibiting prostaglandin synthesis and associated inflammation and pain. This agent may also activate mitogen-activated protein kinase (p38MAPK), thereby inducing apoptosis in cancer cells. (NCI04)

**Synonyms:** - Benzoic acid, 2-hydroxy-, monosodium salt - SODIUM SALICYLATE - Salicylate, sodium - Sodium salicylate - sodium salicylate