Recombinant Insulin-Like Growth Factor

**Semantic type:** Chemical Viewed Functionally

**Definition:** A recombinant human antiapoptotic growth factor. Recombinant insulin-like growth factor (IGF) binds to and activates the insulin and IGF receptors; activation of these receptors initiates intracellular phosphorylation events and the activation of several signaling pathways, thereby promoting cellular proliferation and inhibiting apoptosis. High levels of circulating endogenous insulin-like growth factor may indicate a poor prognosis in some cancers. (NCI04)

**Synonyms:** - Rh IGF - Rh Insulin Like Growth Factor - Somatomedin