Bucillamine

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable derivative of the endogenous amino acid cysteine with two donatable thiol groups, with potential antioxidant and anti-inflammatory activities. Upon oral administration, bucillamine enters cells rapidly via the same pathway as cysteine and replenishes the thiol group in glutathione (GSH), thereby increasing intracellular GSH levels and GSH activity. GSH is an antioxidant and plays an important protective role in oxidative stress and injury. Bucillamine may have additional anti-inflammatory effects, though the mechanisms of action have yet to be fully elucidated.

**Synonyms:** - BUCILLAMINE - N-(2-Mercapto-2-methylpropionyl)-L-cysteine