Efatutazone

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable thiazolidinedione and an agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma thus inducing cell differentiation and apoptosis, leading to a reduction in cellular proliferation. PPAR-gamma is a nuclear hormone receptor and a ligand-activated transcription factor that controls the expression of genes involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation.

**Synonyms:** - 2,4-Thiazolidinedione, 5-((4-((6-(4-Amino-3,5-Dimethylphenoxy)-1-Methyl-1H-Benzimidazol-2-yl)Methoxy)Phenyl)Methyl)- - EFATUTAZONE - Inolitazone - Rac-5-((4-((6-(4-Amino-3,5-Dimethylphenoxy)-1-Methyl-1H-Benzimidazol-2-yl)Methoxy)Phenyl)Methyl)-1,3-Thiazolidine-2,4-Dione