Lacosamide

**Semantic type:** Pharmacologic Substance

**Definition:** A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.

**Synonyms:** - (2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide - ADD 234037 - Erlosamide - Harkoseride - LACOSAMIDE - SPM 927 - Vimpat