FGFR4 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** Mutation of the fibroblast growth factor receptor 4 gene which is located on the long arm of chromosome 5. It has been described in patients with childhood rhabdomyosarcoma. Overexpression of this gene in these patients is associated with advanced stage disease and poor survival.

**Synonyms:** - CD334 Gene Mutation - FGFR-4 Gene Mutation - FGFR4 mutation - Fibroblast Growth Factor Receptor 4 Gene Mutation - JTK2 Gene Mutation - TKF Gene Mutation