Prorenoate

**Semantic type:** Pharmacologic Substance

**Definition:** A steroidal aldosterone antagonist with potassium-sparing diuretic activity. Prorenoate antagonizes the activity of aldosterone at the mineralocorticoid receptor in the nephron and thereby prevents sodium reabsorption. This interferes with the sodium/potassium exchanger and causes sodium and water excretion while reducing potassium excretion.

**Synonyms:** - 3'H-Cyclopropa(6,7)Pregna-4,6-Diene-21-Carboxylic Acid, 6,7-Dihydro-17-Hydroxy-3-Oxo-, (6Alpha,7Alpha,17Alpha)- - 6,7-Dihydro-17-Hydroxy-3-Oxo-3'H-Cyclopropa(6,7)-17Alpha-Pregna-4,6-Diene-21-Carboxylate - PRORENOATE