Protamine Sulfate

**Semantic type:** Pharmacologic Substance

**Definition:** The sulfate salt form of protamine, a highly basic protein rich in arginine and a heparin antagonist, that can be used to neutralize heparin-induced anticoagulation. Upon intravenous administration, the cationic hydrogenated protamine reacts with anionic heparin to form an inactive salt aggregate, which has no anticoagulant activity. Protamine, when administered alone in the absence of heparin, is a weak anticoagulant.

**Synonyms:** - PROTAMINE SULFATE - Protamine Sulphate - Protamine sulfate