PDGFRA Gene Rearrangement

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** Rearrangement of the PDGFRA gene, resulting in the formation of a fusion transcript and aberrant tyrosine kinase activity. It has been described in hematologic malignancies usually presenting as chronic eosinophilic leukemia.

**Synonyms:** - CD140A Gene Rearrangement - PDGFR-2 Gene Rearrangement - PDGFR2 Gene Rearrangement - PDGFRA Rearrangement - PDGFRalpha Gene Rearrangement - Platelet-Derived Growth Factor Receptor Alpha Gene Rearrangement - RHEPDGFRA Gene Rearrangement