PDGFRB Gene Rearrangement

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** Rearrangement of the PDGFRB gene, resulting in the formation of a fusion transcript and aberrant tyrosine kinase activity. It has been described in myeloid malignancies usually presenting as chronic myelomonocytic leukemia.

**Synonyms:** - CD140b Gene Rearrangement - JTK12 Gene Rearrangement - PDGFR1 Gene Rearrangement - Platelet Derived Growth Factor Receptor Beta Gene Rearrangement