PICALM wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PICALM wild-type allele is located in the vicinity of 11q14 and is approximately 112 kb in length. This allele, which encodes phosphatidylinositol-binding clathrin assembly protein, is involved in the modulation of receptor mediated endocytosis. Genetic variation may be associated with Alzheimer's Disease. Diffuse histiocytic lymphomas are associated with a translocation, t(10;11)(p13;q14), involving this gene and the MLLT10 gene.

**Synonyms:** - CALM - CLTH - LAP - Phosphatidylinositol Binding Clathrin Assembly Protein wt Allele