CR1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CR1 wild-type allele is located in the vicinity of 1q32 and is approximately 146 kb in length. This allele, which encodes complement receptor type 1 protein, plays a role in complement-mediated immunity. Genetic polymorphisms are associated with the extent of malarial rosetting, and can confer protection against severe malaria. Genetic variation of the gene may contribute to Alzheimer's Disease.

**Synonyms:** - C3BR - C4BR - CD35 - Complement Component (3b/4b) Receptor 1 (Knops Blood Group) wt Allele - Complement Component (3b/4b) Receptor 1, Including Knops Blood Group System Gene - KN