Cannabinol

**Semantic type:** Pharmacologic Substance

**Definition:** A cannabinoid isolated from the plant Cannabis that is a metabolite of tetrahydrocannabinol (THC), with potential immunosuppressive and anti-inflammatory activities. Cannabinol preferentially binds to the cannabinoid G-protein coupled receptor CB2, which is mainly expressed on a variety of immune cells, such as T-cells, B-cells, macrophages and dendritic cells. Stimulation of CB2 receptors by cannabinol may both trigger apoptosis in these cells and inhibit the production of a variety of cytokines. Cannabinol exerts minimal affinity for CB1 and has a weak effect on the central nervous system.

**Synonyms:** - 3-Amyl-1-hydroxy-6,6,9-trimethyl-6H-dibenzo(b,d)pyran - 6,6,9-Trimethyl-3-pentyl-6H-dibenzo(b,d)pyran-1-ol - CANNABINOL - CBN