Acyl-CoA Dehydrogenase, Short-Chain Deficiency

**Semantic type:** Disease or Syndrome

**Definition:** A genetic disorder characterized by deficiency of the enzyme short-chain acyl-coenzyme A dehydrogenase that metabolizes short-chain fatty acids. Signs and symptoms appear in infancy or childhood and may be triggered during fasting or illness. They include vomiting, hypoglycemia, lethargy, hypotonia and failure to thrive.

**Synonyms:** - SCAD - Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD) - Short-Chain Acyl-Coenzyme A Dehydrogenase Deficiency (SCAD)