Hepatosplenic T-Cell Lymphoma

**Semantic type:** Neoplastic Process

**Definition:** An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic T-cells, usually of gamma/delta T-cell type. It is characterized by the presence of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A similar infiltrating pattern is also present in the spleen and bone marrow that are usually involved at the time of the diagnosis.

**Synonyms:** - Hepatosplenic Gamma/Delta T-Cell Lymphoma - Hepatosplenic T-cell lymphoma - Hepatosplenic T-cell lymphoma - Hepatosplenic gamma-delta cell lymphoma